Dear Author,
Core Profile unlikely provides any noticeable performance boost,
although OCCT will not perform additional OpenGL calls in this context.
The main reason for this option is to allow OCCT to use new OpenGL features on drivers implementing compatibility profile up to version 2.1 only - which is the case only on OS X and Linux systems for the moment.
In other cases (e.g. on WIndows) this option will just reduce rendering capabilities (like line width limited to 1 pixel).
So if your application does not suffer from these issues - it is unlikely you really need to activate this option.
It should be noted, however, that several bugs with Core Profile have been fixed after OCCT 6.9.0 release,
and some rarely used functionality is not yet available in this mode.
Otherwise you can safely use this option - the simplest way is just to try.
Best regards
FSR